Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응
Research Article
[키워드] absence
accompanied
adaptive immune responses
Anti-viral
anti-viral IFN
anti-viral response
antiviral responses
Asymptomatic
asymptomatic SARS-CoV-2 infected subjects
Cell
cells
cellular
characterized
chemokine
chemokines
circulating
contribute
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 pathogenesis
COVID-19 patient
Critically ill
Critically ill patient
critically ill patients
cytokine
Cytokine storm
Cytokines
death
Defense
dendritic cell
dendritic cells
disease severity
early phase
elevated
ENhance
epithelial cells
event
Evidence
Ex vivo
expression
fine-tune
Frequency
hospitalized patient
hospitalized patients
Host
host defense
Host-directed therapies
host-directed therapy
human peripheral blood mononuclear cell
IFN
IFN-stimulated gene
Immune cell
immune cells
immune responses
Immunity
IMPROVE
in vitro
induce
Infection
Inflammatory cytokine
Inflammatory cytokines
inflammatory phenotype
inhibiting viral replication
Innate
innate immune response
Innate immunity
Interaction
interferon
interferons
investigated
low frequency
Lung epithelial cells
mechanism
mononuclear cell
multi-organ failure
neuropilin
observation
Pathogenesis
PBMC
PD-L1 marker
pDC/type I IFN axis
Peripheral blood
pharmacological strategy
phenotype
plasmacytoid dendritic cell
plasmacytoid dendritic cells
pro-inflammatory cytokine
pro-inflammatory cytokines
producing
productive viral replication
progression
protective role
regulate
Regulation
released
responsible
resulting
SARS-CoV-2
SARS-CoV-2 infected subject
SARS-COV-2 infection
SARS-CoV-2 pandemic
secreted
secretion
serum
severe COVID-19
Severe COVID-19 Infection
severe COVID-19 patients
stratified
the cytokine storm
the interferon
tissue damage
TLR7/8
type I
type I and III IFNs
type I and III interferons
Type I IFN
type I IFN producing cells
Viral
viral replication
Viral resistance
virus
viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article